Antibody Engineering Group

Head of the Research Group

Prof. Urpo Lamminmäki, PhD

My research is largely focused on recombinant antibodies and other bioaffinity molecules. I am interested in developing techniques used for tailoring such molecules as well as applications of these molecules in various fields including diagnostics, drug development, and biomarker discovery.

✉️ urplammi@utu.fi

UTU ResearchPortal Page

Latest publication: Huhtinen, O. A., Salbo, R., Lamminmäki, U. & Prince, S. Selection of Biophysically Favorable Antibody Variants Using Modified Flp-In CHO Mammalian Display Platform. Frontiers in Bioengineering and Biotechnology 11, 1170081 (2023).

Senior Researchers

Eeva-Christine Brockmann, PhD

Senior Researcher

✉️ eechbr@utu.fi

UTU ResearchPortal Page

Latest publication: Hietanen, E. et al. Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein. Scientific Reports 12, 13453 (2022).

University Teachers

Tuomas Huovinen, PhD

University Lecturer

✉️ tuohuo@utu.fi

UTU ResearchPortal Page

Latest publication: Kulmala, A., Lappalainen, M., Lamminmäki, U. & Huovinen T. Synonymous Codons and Hydrophobicity Optimization of Post-translational Signal Peptide PelB Increase Phage Display Efficiency of DARPins ACS Synthetic Biology 11, 3174–3181 (2022).

Hanna Sanmark, PhD

University Teacher

In my research, I construct antibody phage libraries and use these libraries to develop binders with novel specificities. Together with my coworkers, I have built several universal phage libraries and at the moment new libraries with improved characteristics are under construction using molecular biology methods. Phage display is used to enrich specific binders from the libraries. The method can be used to create binders against any target antigen.

✉️ hansan@utu.fi

UTU ResearchPortal Page

Latest publication: Salmela, M. et al. Molecular tools for selective recovery and detection of lignin-derived molecules. Green Chemistry 20, 2829-2839 (2018).

Postdoctoral Researchers

Angel Garcia de Lucas, PhD

Postdoctoral Researcher

✉️ angel.garciadelucas@utu.fi

UTU ResearchPortal Page

Latest publication: de Lucas, Á. G., Lamminmäki, U. & López-Picón, F. R. ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience. Biomolecules 13, 164 (2023).

Doctoral Researchers

Sultana Akter

Project Researcher/Doctoral Researcher

✉️ suakte@utu.fi

UTU ResearchPortal Page

Latest publication: Akter, S. & Lamminmäki, U. A 15-min non-competitive homogeneous assay for microcystin and nodularin based on time-resolved Förster resonance energy transfer (TR-FRET). Analytical and Bioanalytical Chemistry 413, 6159–6170 (2021).

Sami Oksanen

Doctoral Researcher

In my research, I focus on exploring the vast possibilities of using next (and third) generation sequencing technologies to enhance antibody screening in terms of throughput, accuracy, and efficiency. Equipped with a strong DIY attitude, I love delving deep into methods I use in my projects, even if it means learning a totally new programming language from scratch. Python, UNIX, 3D printing and microcontrollers have become essential tools in my arsenal, providing solutions to nearly any challenge encountered.

✉️ sami.j.oksanen@utu.fi

UTU ResearchPortal Page